Pathology MCQs
Pathology MCQs are designed to test a student's understanding of disease mechanisms, histopathology, and clinical correlations. Questions range from general pathology to systemic diseases affecting organs like the liver, lungs, heart, and kidneys. Ideal for MDCAT, NTS, USMLE, and FCPS aspirants, these quizzes help reinforce critical concepts and bridge the gap between theory and clinical application.
Q: Acute phase reactant elevated in inflammation
A) C-reactive protein
B) Albumin
C) Fibrinogen
D) Hemoglobin
✅ Correct Answer: A
Explanation: C-reactive protein increases in response to cytokines and is a marker of systemic inflammation.
Q: Acellular, amorphous, eosinophilic material seen in amyloidosis
A) Keratin
B) Collagen
C) Elastin
D) Amyloid
✅ Correct Answer: D
Explanation: Amyloid appears as pink, amorphous deposits in tissues with H&E staining.
Q: Hypertrophy and hyperplasia coexist in
A) Brain
B) Uterus during pregnancy
C) Skeletal muscle
D) Cardiac muscle
✅ Correct Answer: B
Explanation: The uterus undergoes both hypertrophy and hyperplasia during pregnancy.
Q: Hallmark feature of irreversible cell injury
A) Fatty change
B) Loss of ATP
C) Plasma membrane rupture
D) Cell swelling
✅ Correct Answer: C
Explanation: Rupture of the plasma membrane indicates irreversible cell injury and cell death.
Q: Melanin is produced by
A) Langerhans cells
B) Melanocytes
C) Keratinocytes
D) Fibroblasts
✅ Correct Answer: B
Explanation: Melanocytes in the basal layer of the epidermis produce melanin, contributing to skin pigmentation.
Q: Coagulative necrosis retains
A) Organelle function
B) Cell outline
C) Nucleus
D) DNA
✅ Correct Answer: B
Explanation: Cell outlines are preserved in coagulative necrosis, despite loss of nuclear detail.
Q: Histamine released during inflammation causes
A) Vasodilation and increased permeability
B) Vasoconstriction
C) Fever
D) Blood clotting
✅ Correct Answer: A
Explanation: Histamine induces vasodilation and increases vascular permeability during early inflammation.
Q: Liquefactive necrosis is common in
A) Lung
B) Heart
C) Brain
D) Kidney
✅ Correct Answer: C
Explanation: Brain tissue undergoes liquefactive necrosis due to its high lipid content and enzyme activity.
Q: Hallmark of chronic inflammation
A) Short duration
B) Absence of immune cells
C) Neutrophil infiltration
D) Fibrosis
✅ Correct Answer: D
Explanation: Chronic inflammation leads to tissue destruction and fibrosis due to prolonged immune activity.
Q: Serous inflammation is marked by
A) Pus formation
B) Watery fluid with low protein
C) Fibrin exudate
D) Blood accumulation
✅ Correct Answer: B
Explanation: Serous inflammation produces a clear, protein-poor fluid, such as in blisters.