Pathology MCQs
Pathology MCQs are designed to test a student's understanding of disease mechanisms, histopathology, and clinical correlations. Questions range from general pathology to systemic diseases affecting organs like the liver, lungs, heart, and kidneys. Ideal for MDCAT, NTS, USMLE, and FCPS aspirants, these quizzes help reinforce critical concepts and bridge the gap between theory and clinical application.
Q: Presence of Reed-Sternberg cells indicates
A) Non-Hodgkin lymphoma
B) Multiple myeloma
C) Chronic lymphocytic leukemia
D) Hodgkin lymphoma
✅ Correct Answer: D
Explanation: Reed-Sternberg cells are characteristic of Hodgkin lymphoma, aiding its diagnosis.
Q: Role of macrophages in granulomas
A) Histamine release
B) Vasodilation
C) Antibody production
D) Giant cell formation
✅ Correct Answer: D
Explanation: Macrophages transform into multinucleated giant cells within granulomas to contain persistent pathogens.
Q: Amyloidosis involves deposition of
A) Abnormal proteins
B) Calcium
C) Lipids
D) Glycogen
✅ Correct Answer: A
Explanation: Amyloidosis is caused by extracellular deposition of misfolded proteins that form insoluble fibrils.
Q: Anemia associated with chronic disease shows
A) Target cells
B) Microcytic hypochromic RBCs
C) Megaloblastic features
D) Normocytic normochromic RBCs
✅ Correct Answer: D
Explanation: Chronic disease often causes normocytic normochromic anemia due to impaired iron utilization.
Q: Hemosiderin is a storage form of
A) Calcium
B) Copper
C) Iron
D) Zinc
✅ Correct Answer: C
Explanation: Hemosiderin stores excess iron in tissues, visible with Prussian blue staining.
Q: Epithelioid cells in granulomas derive from
A) Neutrophils
B) Macrophages
C) B cells
D) Mast cells
✅ Correct Answer: B
Explanation: Macrophages transform into epithelioid cells during granulomatous inflammation.
Q: Hyperplasia can be physiological in
A) Endometrial lining during menstrual cycle
B) Scar formation
C) Atherosclerosis
D) Prostate cancer
✅ Correct Answer: A
Explanation: Endometrial hyperplasia during the menstrual cycle is a normal, hormone-regulated process.
Q: Loss of nucleus in cell injury is referred to as
A) Pyknosis
B) Karyorrhexis
C) Karyolysis
D) Lysis
✅ Correct Answer: C
Explanation: Karyolysis is the dissolution of nuclear material due to enzymatic degradation.
Q: Fat necrosis is commonly seen in
A) Myocardial infarction
B) Brain infarct
C) Liver cirrhosis
D) Breast trauma
✅ Correct Answer: D
Explanation: Fat necrosis often results from trauma to fatty tissues like the breast or pancreas.
Q: Primary mediator of fever during inflammation
A) TNF-beta
B) IL-4
C) IL-10
D) IL-1
✅ Correct Answer: D
Explanation: Interleukin-1 acts on the hypothalamus to raise body temperature and induce fever.