Pathology MCQs
Pathology MCQs assess knowledge of disease mechanisms, histopathology, and systemic conditions. Covering organs like liver, lungs, heart, and kidneys, they help MDCAT, USMLE, NTS, and FCPS aspirants strengthen concepts and clinical understanding.
Q: Common cause of fibrinoid necrosis in vessels
A) Hypoxia
B) Hypertension
C) Diabetes
D) Obesity
✅ Correct Answer: B
Explanation: Fibrinoid necrosis results from immune-mediated or hypertensive vascular injury.
Q: Reactive oxygen species cause cell damage through
A) Osmotic imbalance
B) Increased protein synthesis
C) Lipid peroxidation and DNA damage
D) Direct enzyme activation
✅ Correct Answer: C
Explanation: Reactive oxygen species damage membranes, proteins, and DNA, leading to cell injury or death.
Q: Fatty change in the liver is most often associated with
A) Viral hepatitis
B) Hypoxia
C) Iron overload
D) Alcohol abuse
✅ Correct Answer: D
Explanation: Alcohol interferes with lipid metabolism, leading to triglyceride accumulation in hepatocytes.
Q: A granuloma typically consists of
A) Neutrophils and plasma cells
B) Giant cells, macrophages, and lymphocytes
C) Fibroblasts and endothelial cells
D) Basophils and mast cells
✅ Correct Answer: B
Explanation: Granulomas are organized collections of immune cells formed in response to persistent pathogens or foreign material.
Q: The most common site of amyloid deposition in systemic amyloidosis
A) Kidney
B) Skin
C) Brain
D) Liver
✅ Correct Answer: A
Explanation: The kidneys are frequently affected by amyloid, leading to proteinuria and nephrotic syndrome.