Pathology MCQs
Pathology MCQs are designed to test a student's understanding of disease mechanisms, histopathology, and clinical correlations. Questions range from general pathology to systemic diseases affecting organs like the liver, lungs, heart, and kidneys. Ideal for MDCAT, NTS, USMLE, and FCPS aspirants, these quizzes help reinforce critical concepts and bridge the gap between theory and clinical application.
Q: Acellular pink amorphous deposits in glomeruli suggest
A) Amyloidosis
B) Inflammation
C) Hemorrhage
D) Necrosis
✅ Correct Answer: A
Explanation: Amyloid appears as homogeneous, eosinophilic deposits in tissues under H&E stain.
Q: Increased mitotic figures are commonly seen in
A) Benign tumors
B) Malignant tumors
C) Granulomas
D) Ischemic tissue
✅ Correct Answer: B
Explanation: Malignant tumors exhibit increased mitosis due to uncontrolled proliferation.
Q: Hyperemia in acute inflammation results from
A) Arterial vasoconstriction
B) Venous thrombosis
C) Arteriolar vasodilation
D) Lymphatic obstruction
✅ Correct Answer: C
Explanation: Arteriolar dilation leads to increased blood flow and redness at the site of injury.
Q: A tumor arising from glandular epithelium is called
A) Sarcoma
B) Lipoma
C) Fibroma
D) Adenoma
✅ Correct Answer: D
Explanation: Adenomas are benign tumors derived from glandular epithelial cells.
Q: Hemosiderin pigment accumulation is caused by
A) Lipid oxidation
B) Iron storage after hemorrhage
C) Calcium overload
D) Glycogen storage
✅ Correct Answer: B
Explanation: Hemosiderin forms from breakdown of hemoglobin and stores excess iron in tissues.
Q: A non-caseating granuloma is commonly seen in
A) Fungal infections
B) Syphilis
C) Tuberculosis
D) Sarcoidosis
✅ Correct Answer: D
Explanation: Sarcoidosis produces non-caseating granulomas without central necrosis.
Q: The key mediator responsible for fever in inflammation
A) Histamine
B) Prostaglandin E2
C) Leukotriene B4
D) Nitric oxide
✅ Correct Answer: B
Explanation: Prostaglandin E2 resets the hypothalamic temperature set point, causing fever.
Q: A dominant feature of apoptosis on microscopy
A) Cell swelling
B) Karyolysis
C) Cell fragmentation into apoptotic bodies
D) Neutrophilic infiltration
✅ Correct Answer: C
Explanation: Apoptotic cells shrink and fragment into membrane-bound apoptotic bodies.
Q: A tumor's grade refers to
A) Size only
B) Genetic mutation
C) Degree of differentiation
D) Stage of spread
✅ Correct Answer: C
Explanation: Tumor grade evaluates cellular differentiation and predicts aggressiveness.
Q: The first cells to arrive at the site of injury
A) Lymphocytes
B) Platelets
C) Neutrophils
D) Macrophages
✅ Correct Answer: C
Explanation: Neutrophils respond quickly to chemotactic signals and dominate the early phase.