Pharmacology MCQs
Pharmacology MCQs help learners understand the actions, interactions, uses, and side effects of various drugs. These questions cover pharmacokinetics, pharmacodynamics, drug classifications, and toxicology. Practicing them aids in mastering this crucial medical subject and performing well in exams such as MDCAT, USMLE, FCPS, and NTS.
Q: Warfarin acts by inhibiting
A) Fibrinolysis
B) Thrombin activity
C) Vitamin K epoxide reductase
D) Platelet function
✅ Correct Answer: C
Explanation: Warfarin prevents clot formation by inhibiting the enzyme that recycles vitamin K.
Q: Primary adverse effect of aminoglycosides
A) Constipation
B) Hypoglycemia
C) Nephrotoxicity
D) Bronchospasm
✅ Correct Answer: C
Explanation: Aminoglycosides can accumulate in renal tissue and damage nephrons.
Q: Naloxone is administered to reverse
A) Acetaminophen toxicity
B) Alcohol poisoning
C) Benzodiazepine toxicity
D) Opioid overdose
✅ Correct Answer: D
Explanation: Naloxone is an opioid receptor antagonist used to reverse opioid-induced respiratory depression.
Q: Therapeutic use of salicylates
A) Analgesia
B) Antipsychotic action
C) Sedation
D) Antiviral activity
✅ Correct Answer: A
Explanation: Salicylates like aspirin are effective pain relievers and anti-inflammatory agents.
Q: Use of atropine in clinical emergency
A) Seizures
B) Bradycardia
C) Hyperkalemia
D) Anemia
✅ Correct Answer: B
Explanation: Atropine blocks vagal stimulation to the heart, raising heart rate in bradycardia.
Q: Drug causing ototoxicity and nephrotoxicity
A) Azithromycin
B) Chloramphenicol
C) Amikacin
D) Ceftriaxone
✅ Correct Answer: C
Explanation: Amikacin, an aminoglycoside, is toxic to both the kidneys and the auditory system.
Q: Prophylactic drug for rheumatic fever
A) Ciprofloxacin
B) Tetracycline
C) Penicillin
D) Erythromycin
✅ Correct Answer: C
Explanation: Long-term use of penicillin is recommended to prevent recurrence of rheumatic fever.
Q: Mode of action of sulfonamides
A) Inhibit DNA gyrase
B) Inhibit folate synthesis
C) Disrupt cell membrane
D) Interfere with peptidoglycan
✅ Correct Answer: B
Explanation: Sulfonamides block dihydropteroate synthase, an enzyme in folate synthesis.
Q: Cholinergic crisis is managed using
A) Pilocarpine
B) Atropine
C) Neostigmine
D) Physostigmine
✅ Correct Answer: B
Explanation: Atropine, a muscarinic antagonist, counters the excessive cholinergic activity.
Q: Teratogenic drug leading to phocomelia
A) Carbamazepine
B) Valproic acid
C) Thalidomide
D) Phenytoin
✅ Correct Answer: C
Explanation: Thalidomide causes limb deformities when used during early pregnancy.