Pharmacology MCQs
Pharmacology MCQs help learners understand the actions, interactions, uses, and side effects of various drugs. These questions cover pharmacokinetics, pharmacodynamics, drug classifications, and toxicology. Practicing them aids in mastering this crucial medical subject and performing well in exams such as MDCAT, USMLE, FCPS, and NTS.
Q: Tetracyclines must not be taken with dairy due to
A) Chelation with calcium
B) Increased absorption
C) Enzyme induction
D) Delayed excretion
✅ Correct Answer: A
Explanation: Calcium binds tetracycline, reducing its gastrointestinal absorption.
Q: Carbamazepine is useful in treating
A) Hypertension
B) Tuberculosis
C) Ulcers
D) Partial seizures
✅ Correct Answer: D
Explanation: It stabilizes neuronal membranes by blocking voltage-gated sodium channels.
Q: The analgesic effect of NSAIDs results from inhibition of
A) Acetylcholine activity
B) Prostaglandin synthesis
C) Dopamine pathways
D) GABA receptors
✅ Correct Answer: B
Explanation: NSAIDs block cyclooxygenase enzymes involved in prostaglandin production.
Q: Sildenafil improves erectile function by enhancing
A) Beta oxidation
B) Estrogen production
C) cGMP levels
D) Calcium influx
✅ Correct Answer: C
Explanation: It inhibits phosphodiesterase-5, prolonging cGMP-mediated vasodilation.
Q: The main adverse effect of chloramphenicol is
A) Aplastic anemia
B) Tinnitus
C) Gingival hyperplasia
D) Tachycardia
✅ Correct Answer: A
Explanation: Chloramphenicol can severely suppress bone marrow function.
Q: Antacids neutralize stomach acid through
A) Receptor blockage
B) Hormone suppression
C) Chemical reaction
D) Enzyme inhibition
✅ Correct Answer: C
Explanation: They act directly on gastric acid to reduce acidity.
Q: Hydralazine lowers blood pressure by promoting
A) Diuresis
B) Vagal stimulation
C) Bronchoconstriction
D) Arterial vasodilation
✅ Correct Answer: D
Explanation: Hydralazine relaxes smooth muscle in arterioles.
Q: Dopamine agonists like bromocriptine are used to treat
A) Parkinson’s disease
B) Hyperthyroidism
C) Hypertension
D) Bacterial infections
✅ Correct Answer: A
Explanation: These drugs stimulate dopamine receptors to relieve Parkinsonian symptoms.
Q: Vancomycin administration requires careful monitoring due to risk of
A) Hypoglycemia
B) Constipation
C) Nephrotoxicity
D) Hair loss
✅ Correct Answer: C
Explanation: High doses may impair kidney function.
Q: Baclofen reduces spasticity by mimicking
A) Acetylcholine
B) GABA
C) Norepinephrine
D) Glutamate
✅ Correct Answer: B
Explanation: Baclofen activates GABA-B receptors, decreasing nerve transmission in the spinal cord.